讲座主题：活性硫的生物成像探针
时间：2024年10月9日下午3：00
地点：运动医学院会议室
讲座嘉宾：陈巍教授、博士生导师
嘉宾介绍：
教育与工作经历
2013年1月 毕业于中国科学院化学研究所，获分析化学理学博士
2021年6月至今 华中科技大学武汉光电国家研究中心教授
主要研究方向
1) 基于特异性化学反应的小分子光学探针与生物成像；
2) 光学性质可调控的新型近红外荧光染料与生物成像；
3）生物体内与疾病相关的活性物质的调控与生物成像。
期刊论文
W. Chen, T. Matsunaga, D. L Neill, C. Yang, T. Akaike, M. Xian. Rational Design of a Dual-Reactivity Based Fluorescent Probe for Visualizing Intracellular HSNO. Angew. Chem. Int. Ed. 2019, 58, 16067-16070. ([Selected as a “Hot Paper” by the Editors][X-MOL News] [TAP-1 is the first fluorescent probe for HSNO])
W. Chen†, C. Liu† (†Equal contribution), B. Peng, Y. Zhao, A. Pacheco, M. Xian. New fluorescent probes for sulfane sulfurs and the application in bioimaging. Chem. Sci. 2013, 4, 2892-2896.([Chemistry World News] [SSP is the first fluorescent probe for sulfane sulfurs][Probe SSP4 is now commercially available from Dojindo Molecular Technologies, Inc.])
W. Chen, S. Xu, J. J. Day, D. Wang, M. Xian. A General Strategy for Development of Near-Infrared Fluorescent Probes for Bioimaging. Angew. Chem. Int. Ed. 2017, 56, 16611-16615. ([Science Newsline] [ScienceDaily News] [EurekAlert! Science News] [National Science Foundation News] [Medical News] [Technology Networks] [ News] [Health Medicine Network News] [Lab Manager News] [Drug Target Review News])
W. Chen, A. Pacheco, Y. Takano, J. J. Day, K. Hanaoka, M. Xian. A single fluorescent probe to visualize hydrogen sulfide and hydrogen polysulfides with different fluorescence signals. Angew. Chem. Int. Ed. 2016, 55, 9993-9996.([Highlighted as a Very Important Paper (VIP)] [ScienceDaily News] [ News] [Health Medicine Network News] [EurekAlert! Science News] [DDP-1 is the first fluorescent probe that can visualize H2S and H2Sn with different fluorescence signals])
W. Chen, E. W. Rosser, T. Matsunaga, A. Pacheco, T. Akaike, M. Xian. The development of fluorescent probes for visualizing intracellular hydrogen polysulfides. Angew. Chem. Int. Ed. 2015, 54, 13961-13965. [PSP-3 is the most sensitive probe reported to date for H2Sn]
V. S. Lin†, W. Chen† (†Equal contribution), M. Xian, C. J. Chang. Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems. Chem. Soc. Rev. 2015, 44, 4596-4618. [From themed collection Imaging Agents]
C. Liu†, W. Chen† (†Equal contribution), W. Shi, B. Peng, Y. Zhao, H. Ma, M. Xian. Rational design and bioimaging applications of highly selective fluorescence probes for hydrogen polysulfides. J. Am. Chem. Soc. 2014, 136, 7257-7260.([DSP is the first fluorescent probe for H2Sn (n>1)] [Probe DSP-3 is now commercially available from Chemodex Ltd])
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运动医学院
2024年10月8日
